Phenotypes Associated with This Genotype

Genotype
MGI:6718507

• Allelic Composition: Dzip1^tm1Sasl/Dzip1^tm1Sasl; Nfatc1^tm1.1(cre)Bz/Nfatc1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal mitral valve morphology ( J:291454 )

• reduced cilia length in valve mesenchyme

• adult mice exhibit myxomatous mitral valves with loss of normal extracellular matrix distribution

abnormal mitral valve cusp morphology ( J:291454 )

• elongated leaflet

mitral valve prolapse ( J:291454 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitral valve prolapse		DOID:988	OMIM:157700 OMIM:607829 OMIM:610840	J:291454