Analysis Tools
homeostasis/metabolism
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• mice exhibit normal glucose clearance
(J:307284)
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N |
(J:307284)
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• at 14 months of age
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• in male, but not female, mice
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• slight with increased transferrin saturation
• however, iron levels are normal in the brain and erythropoiesis organ
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• decreased alpha-amylase activity in male, but not female, mice
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• at 14 months of age
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• at 14 months of age
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• in male, but not female, mice
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• in male, but not female, mice
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• in male, but not female, mice
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• at 14 months of age
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nervous system
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• impaired in the cerebellar cortex
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astrocytosis
(
J:307284
)
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• in the medulla oblongata
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• reduced dopamine positive neuroaxonal fibres in the substantia nigra
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• progressive with eosinophil spheroids and swollen structures in the basal ganglia, thalamus, cerebral cortex, medulla oblongata, spinal cord, and deep cerebellar nuclei
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vision/eye
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• in some mice
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behavior/neurological
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• increased falls on a balance beam and longer time to traverse a beam ladder with increased hindpaw slips
• however, forepaw slips rate is normal
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• increased distance traveled
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• impaired social recognition memory in male, but not female, mice
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hematopoietic system
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• in male, but not female, mice
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• in male, but not female, mice
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anisocytosis
(
J:307284
)
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• MP:0002642
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growth/size/body
hearing/vestibular/ear
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• progressive starting at 17 months in a click-box test
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cellular
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• reduced complex I activity when normalized to citrate synthase activity in the brain
• however, mice exhibit normal citrate synthase activity and normalized respiratory chain complex activity in the heart
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immune system
pigmentation
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• in the retina
• however, no lipofuscin accumulation in the brain
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neurodegeneration with brain iron accumulation 5 | DOID:0110739 |
OMIM:300894 |
J:307284 | |
