Phenotypes Associated with This Genotype

Genotype
MGI:6726265

• Allelic Composition: Tcf20^em1Jwji/Tcf20⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial working memory ( J:306854 )

• in the Y-maze test, mice show a decreased tendency to enter the new arms, indicating disruption of working memory

increased anxiety-related response ( J:306854 )

• in the elevated-plus maze, the moving time in the open arms is reduced, indicating anxiety

abnormal response to social novelty ( J:306854 )

• in the three-chamber test, mice do not prefer to interact with new novel wild-type mice, indicating social interaction defects

circling ( J:306854 )

• mice run in circles in home cages

increased stereotypic behavior ( J:306854 )

• in the marble burying test, mice bury more marbles than wild-type mice, indicating repetitive behavior

• however, mice show normal behavior in the open field test

decreased vocalization ( J:306854 )

• call numbers and total call durations are reduced in pups

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:306854
Phelan-McDermid syndrome		DOID:0080354	OMIM:606232	J:306854