Phenotypes Associated with This Genotype

Genotype
MGI:6726548

• Allelic Composition: Macroh2a1^tm1.1Oxbo/Macroh2a1^tm1.1Oxbo
• Genetic Background: B6.Cg-Macroh2a1^tm1.1Oxbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased eosinophil cell number ( J:293382 )

decreased hematocrit ( J:293382 )

decreased neutrophil cell number ( J:293382 )

decreased B cell number ( J:293382 )

• mice show a lower frequency of B (B220+) cells in the bone marrow

increased lymphocyte cell number ( J:293382 )

increased myeloid cell number ( J:293382 )

• mice show a higher frequency of myeloid (Mac-1+) cells in the bone marrow

• higher frequencies of myeloid cells and lower frequencies of B cells are seen in the peripheral blood of mice receiving mutant bone marrow cells in transplantation assays, indicating a myeloid differentiation bias

• however, total bone marrow cellularity and frequency of LSK CD48-CD150+ HSCs are normal

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:293382 )

decreased circulating aspartate transaminase level ( J:293382 )

immune system

increased eosinophil cell number ( J:293382 )

decreased neutrophil cell number ( J:293382 )

decreased B cell number ( J:293382 )

• mice show a lower frequency of B (B220+) cells in the bone marrow

increased lymphocyte cell number ( J:293382 )

cellular

increased sensitivity to induced cell death ( J:293382 )

• enhanced susceptibility to radiation-induced death and cell damage

• mice show a decrease in long-term hematopoietic stem cell (LT-HSC) frequency following low-dose and high-dose irradiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myelodysplastic syndrome		DOID:0050908	OMIM:614286	J:293382