Phenotypes Associated with This Genotype

Genotype
MGI:6727110

• Allelic Composition: Cfap47^em1Fzh/Y
• Genetic Background: C57BL/6-Cfap47^em1Fzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:307391 )

♀N • fertile

teratozoospermia ( J:307391 )

♂ • frequent occurrence of bent flagella

abnormal sperm fibrous sheath morphology ( J:307391 )

♂ • higher rate of unevenly distributed fibrous sheath

kinked sperm flagellum ( J:307391 )

♂ • frequent occurrence of bent flagella

asthenozoospermia ( J:307391 )

♂ • diminished and abnormal sperm motility and progressive motility with high rate of immotile and non-progressive spermatozoa

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)

male infertility ( J:307391 )

♂ • sperm can fertilize eggs through intra-cytoplasmic sperm injection (ICSI) or, at a lower rate, in vitro fertilization (IVF)

♂ • no offspring when mated to WT females

cellular

teratozoospermia ( J:307391 )

♂ • frequent occurrence of bent flagella

abnormal sperm fibrous sheath morphology ( J:307391 )

♂ • higher rate of unevenly distributed fibrous sheath

kinked sperm flagellum ( J:307391 )

♂ • frequent occurrence of bent flagella

asthenozoospermia ( J:307391 )

♂ • diminished and abnormal sperm motility and progressive motility with high rate of immotile and non-progressive spermatozoa

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:307391