Phenotypes Associated with This Genotype

Genotype
MGI:6727907

hm1

• Allelic Composition: Matn4^tm1.1Asz/Matn4^tm1.1Asz
• Genetic Background: B6.129-Matn4^tm1.1Asz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased hematopoietic stem cell proliferation ( J:237230 )

• HSCs show increased competitive repopulation capacity in bone marrow transplantations

• HSCs in liquid culture produce larger colonies with a higher percentage of undifferentiated and mixed colonies; a few days later, undifferentiated colonies start to generate mixed colonies, suggesting that HSCs initially self-renew more before differentiating

decreased hematopoietic stem cell number ( J:237230 )

• mice exhibit decreased Lin^-Sca-1⁺cKit⁺ (LSK) numbers

• however, quiescent hematopoietic stem cell (HSC) and long term-hematopoietic stem cell (LT-HSC) numbers are normal and amounts of myeloid and lymphoid lineages are normal

cellular

increased hematopoietic stem cell proliferation ( J:237230 )

• HSCs show increased competitive repopulation capacity in bone marrow transplantations

• HSCs in liquid culture produce larger colonies with a higher percentage of undifferentiated and mixed colonies; a few days later, undifferentiated colonies start to generate mixed colonies, suggesting that HSCs initially self-renew more before differentiating