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Phenotypes Associated with This Genotype
Genotype
MGI:6729187
Allelic
Composition
Fgf13em1Xuzh/Y
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13em1Xuzh mutation (0 available); any Fgf13 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show a reduction of freezing time in contextual memory indicating impaired associated memory
• mice show a reduction of freezing time in cued memory indicating impaired associated memory
• mice show increased escape latency and reduced time spent in the target quadrant during the training process of the Morris water maze
• in the probe trail of the Morris water maze, mice show less preference for the target quadrant than controls
• mice exhibit reduction of immobility time in the tail suspension test indicating decreased depression-like behavior
• however, mice show no alterations in motor ability in the rotarod test, social interaction behavior in the three-chamber test. anxiety-related behavior, in the novel object recognition test and in spontaneous activity in the open field

cellular
• nearly 40% of cortical neurons grown in culture do not develop into polarized neurons
• cortical neurons grown in culture show increased axon branching
• the percentage of neurons remaining in the white matter or cortical layers V-VI is higher than in controls at P0 and P7 but majority of cortical neurons migrate into layers II-IV at P14, indicating delayed neuronal migration

nervous system
• nearly 40% of cortical neurons grown in culture do not develop into polarized neurons
• cortical neurons grown in culture show increased axon branching
• the percentage of neurons remaining in the white matter or cortical layers V-VI is higher than in controls at P0 and P7 but majority of cortical neurons migrate into layers II-IV at P14, indicating delayed neuronal migration
• mice show laminar defects in the cerebral cortex, with Cux1+ (marking superficial cortical neurons) neurons distributed in both layers II-IV and mislocated throughout layers V-VI, and reduced thickness of superficial cortical layer at P0 but compensated at P7
• axon arbors are more complex and axons project to both the contralateral somatosensory cortex (S1) and secondary somatosensory cortex (S2) cortical regions while in wild-type mice the axons mainly reach the contralateral S1 cortical region
• complexity of contralateral axon projection remains increased at P14
• dendritic spine density in pyramidal neurons from both S1 and CA1 hippocampal regions is decreased

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:307501


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory