Phenotypes Associated with This Genotype

Genotype
MGI:6766588

• Allelic Composition: Hand1^tm5Abfi/Hand1⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:311466 )

• expected numbers of embryos are obtained at E10.5 and E14.5 but reduced numbers of neonates are seen at P1

cardiovascular system

abnormal heart apex morphology ( J:311466 )

• hearts lack a well-defined apex at P60

cardiac hypertrophy ( J:311466 )

• bifurcated hearts appear slightly hypertrophied at P60

• however, cardiac morphology appears normal at E14.5

growth/size/body

cardiac hypertrophy ( J:311466 )

• bifurcated hearts appear slightly hypertrophied at P60

• however, cardiac morphology appears normal at E14.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hypoplastic left heart syndrome	DOID:9955	OMIM:241550 OMIM:614435	J:311466