Phenotypes Associated with This Genotype

Genotype
MGI:6790238

• Allelic Composition: Ank2^em1Bnt/Ank2^em1Bnt
• Genetic Background: C57BL/6J-Ank2^em1Bnt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:277752 )

♂N • male mice exhibit normal responses to non-social and social stimuli, performance on a rotarod, anxiety-like behavior in the light-dark emergence test, short- and long-term novel object recognition memory, learning and memory in a Morris water maze,

enhanced spatial learning ( J:277752 )

♂ • in the reversal phase of a Morris water maze

increased grooming behavior ( J:277752 )

♂ • 2-fold

decreased locomotor activity ( J:277752 )

♂ • in an open field

abnormal social/conspecific interaction behavior ( J:277752 )

♂ • males make small or no territory markings in response to female urine

decreased vocalization ( J:277752 )

♂ • fewer ultrasonic vocalization

nervous system

abnormal brain morphology ( J:277752 )

♂ • small increase in interhemispheric asymmetry in the cortex and overall increased connectivity

abnormal axon morphology ( J:277752 )

♂ • increased branching

♂ • however, primary axon length and dendritic morphology are normal and normal branching levels can be restored with expression of a cDNA encoding the giant Ank2 isoform

abnormal excitatory synapse morphology ( J:277752 )

♂

abnormal miniature excitatory postsynaptic currents ( J:277752 )

♂ • increased frequency and amplitude at P28, but not P60

♂ • however, miniature inhibitory postsynaptic currents are normal

increased miniature excitatory postsynaptic current amplitude ( J:277752 )

♂ • increased mEPSC amplitude at P28, but not P60

increased miniature excitatory postsynaptic current frequency ( J:277752 )

♂ • increased mEPSC frequency at P28, but not P60

decreased paired-pulse facilitation ( J:277752 )

♂ • at P28, but not P60

taste/olfaction

taste/olfaction phenotype ( J:277752 )

♂N • mice exhibit normal olfaction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autistic disorder		DOID:12849	OMIM:209850	J:277752