Phenotypes Associated with This Genotype

Genotype
MGI:6810192

• Allelic Composition: Ppara^em1Tyrb/Ppara^em1Tyrb
• Genetic Background: C57BL/6J-Ppara^em1Tyrb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:313946 )

• mice bury a higher number of marbles in the marble-burying test, indicating higher anxiety

• however, mice do not show differences in the open field test, novel object recognition, Y-maze test, three-chamber social interaction test, home cage activity test, tail suspension test, forced swim test, administration of MK-801-induced locomotor hyperactivity or sucrose preference test

nervous system

abnormal dendritic spine morphology ( J:313946 )

• mice exhibit a decrease in percentage of mature dendritic spines (stubby + mushroom + branched) and an increased percentage immature spines (filipodia + thin)

decreased dendritic spine density ( J:313946 )

• dendritic spine density is lower

• however, mice are healthy without any visible abnormalities in growth or morphology and show normal blood biochemical profiles

decreased prepulse inhibition ( J:313946 )

• mice exhibit reduced prepulse inhibition at prepulse levels of 70, 78, and 82

• however, average startle response is not different from controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:313946