Phenotypes Associated with This Genotype

Genotype
MGI:6828596

hm1

• Allelic Composition: Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:285384 )

• reduced colony forming unit cells

thrombocytopenia ( J:285384 )

decreased hematopoietic stem cell number ( J:285384 )

cellular

increased cellular sensitivity to DNA damaging agents ( J:285384 )

• bone marrow hematopoietic progenitor cells are hypersensitive to mitomycin C compared with wild-type cells