Phenotypes for Fancd2 Fanci MGI:6828597 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} Fanci^tm1.1Itl/Fanci^tm1.1Itl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (82 available)
Fanci^tm1.1Itl mutation (0 available); any Fanci mutation (200 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:285384 )

• fewer than expected mice are born

hematopoietic system

abnormal bone marrow cell morphology/development ( J:285384 )

• reduced colony forming unit cells as in single knock-outs

thrombocytopenia ( J:285384 )

• as in single knock-outs

decreased hematopoietic stem cell number ( J:285384 )

• worse than in single knock-outs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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