Phenotypes Associated with This Genotype

Genotype
MGI:6828730

• Allelic Composition: Zfp804a^em1Yqd/Zfp804a^em1Yqd
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:312498 )

N • mice exhibit normal high frequency stimulation long term depression

decreased dendritic spine density ( J:312498 )

• in cortical and hippocampal neurons

decreased prepulse inhibition ( J:312498 )

♀ • at 6 and 8 months of age in female, but not male, mice

♀ • however, PPI at 2 and 4 months is normal in female and male mice and removal of the ovaries restores female PPI response

behavior/neurological

impaired contextual conditioning behavior ( J:312498 )

• mice exhibit impaired remote memory contextual fear conditioning compared with wild-type mice

impaired spatial learning ( J:312498 )

• mild in female, but not male mice, during training

abnormal spatial reference memory ( J:312498 )

• impaired in female and male mice 8 days after training in a Morris water maze

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:312498