Phenotypes for Foxa2 Pgr MGI:6854709 MGI Mouse

• although blastocysts can attach to the uterine lumen and initiate a decidual response, the decidual region and size of the embryos is significantly smaller on day 5.5 of natural pregnancy

• after induction of artificial decidualization, stimulated horn weight:unstimulated horn weight ratio is significantly lower than that in controls

• decidualization defect can be partially rescued by intrauterine injection of recombinant leukemia inhibitory factor (LIF) prior to the initiation of the decidual response

abnormal endometrial gland development ( J:165229 )

• uteri of 8-wk-old females show a severe defect in endometrial gland development

• loss of endometrial glands results in a marked reduction of leukemia inhibitory factor (Lif) expression on day 3.5 of pseudopregnancy

decreased endometrial gland number ( J:165229 )

• nonpregnant uteri of 8-wk-old females show a severe reduction in the number of endometrial glands relative to control uteri

abnormal embryo invasion ( J:165229 )

• on day 5.5 of pregnancy, embryos fail to exhibit invasion into the uterine stroma through the epithelium

impaired embryo implantation ( J:165229 )

• on day 5.5 of pregnancy, the number of implantation sites is significantly lower than that in control uteri

abnormal uterus physiology ( J:165229 )

• uterus is unable to support embryo invasion and undergo an experimentally induced decidual response with exogenous steroid hormones

reduced female fertility ( J:165229 )

• when mated to wild-type males for a period of 6 months, females exhibit severe subfertility, with significantly fewer litters, pups per litter and total pups born relative to control females

decreased litter size ( J:165229 )

• females produce significantly fewer pups per litter than control females

abnormal decidualization ( J:165229 )