Phenotypes Associated with This Genotype

Genotype
MGI:6887870

hm1

• Allelic Composition: Litaf^tm1.2Cwc/Litaf^tm1.2Cwc
• Genetic Background: C57BL/6-Litaf^tm1.2Cwc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal vacuole morphology ( J:314784 )

• empty vacuoles without intraluminal vesicles in MEFs

• enlarged vacuoles with electron-dense granules in MEFs

• multilamellar cisternal compartments near vacuoles in MEFs

abnormal lysosome physiology ( J:314784 )

• reduced secreted levels in exosomes from MEFs

abnormal exocytosis ( J:314784 )

• reduced secreted levels in exosomes from MEFs