Phenotypes Associated with This Genotype

Genotype
MGI:6888388

ht3

• Allelic Composition: Tubb4a^Jit/Tubb4a^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:321692 )

• mice survive up to approximately 14 weeks

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:321692 )

• motor defects

nervous system

abnormal cerebellar granule cell morphology ( J:321692 )

• mice show progressive degeneration of granule cell neurons such that the inner granule layer is largely devoid of granule cell neurons at P48

cerebellum atrophy ( J:321692 )

• P95 mice have severely atrophic cerebellum with the inner granule layer largely devoid of granule cell neurons at P48

• however, cerebellar phenotypes are less severe than in homozygous Tubb4a^Jit mice

abnormal nervous system tract morphology ( J:321692 )

• reduction in white matter tracts such as corpus callosum, anterior commissures, and striatal fascicles at P95

dysmyelination ( J:321692 )

• mice show progressive degeneration of myelin with reduced myelin at P48 and P95, however reduction in myelin is not as severe as in in homozygous Tubb4a^Jit mice

• cerebellum is severely demyelinated at P95