Phenotypes Associated with This Genotype

Genotype
MGI:6890374

• Allelic Composition: Prickle1^em1Yzou/Prickle1⁺
• Genetic Background: C57BL/6-Prickle1^em1Yzou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:321396 )

• mice exhibit shorter latencies to Pentylenetrazole (PTZ)-induced tonic-clonic seizure indicating reduced seizure threshold

• seizure susceptibility is enhanced more than in homozygous mice

abnormal spatial reference memory ( J:321396 )

• in the Barnes maze task, mice spend similar time in the target quadrant and other quadrants unlike controls that spend more time in the target quadrant, indicating a mild deficit in spatial memory

• however, mice show no differences from wild-type mice in novel object recognition

abnormal social investigation ( J:321396 )

• mice show deficits in sociability in the three-chamber social interaction task

• however, mice show normal social recognition memory in the three-chamber social novelty task

• mice show no differences in anxiety in the open field arena, elevated plus maze, or light-dark transition tasks

nervous system

increased susceptibility to pharmacologically induced seizures ( J:321396 )

• mice exhibit shorter latencies to Pentylenetrazole (PTZ)-induced tonic-clonic seizure indicating reduced seizure threshold

• seizure susceptibility is enhanced more than in homozygous mice

abnormal excitatory synapse morphology ( J:321396 )

• mice show a 35% reduction in the number of excitatory glutamatergic synapses in the hippocampus in adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:321396
progressive myoclonus epilepsy 1B		DOID:0111448	OMIM:612437	J:321396