Phenotypes Associated with This Genotype

Genotype
MGI:7256634

• Allelic Composition: Cacng8^tm1Ran/Cacng8^tm1Ran
• Genetic Background: C57BL/6-Cacng8^tm1Ran

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:322011 )

• mice urinate throughout the cages, even on their nest

• reductions in cage management behaviors indicate reduced social responsibility

impaired active avoidance behavior ( J:322011 )

• in a shuttle box test, mice show reduced latency to enter the compartment and an increased frequency of entries in a recall trial, indicating that mice do not learn to fear the shock lesson and exhibit risk-ignoring behaviors

abnormal emotion/affect behavior ( J:322011 )

• in a drowning rescue test, mice spend less time near the container containing a struggling-against-drowning mouse and have fewer contacting movement traces, indicating reduced empathic behavior

increased exploration in new environment ( J:322011 )

• in the open field, mice exhibit a greater total distance traveled indicating an increase in locomotor response to environmental novelty, a phenotype associated with impulsivity

• however, time in central versus periphery is not different

increased aggression ( J:322011 )

• mice exhibit bare patches in their coats from severe bite wounds, suggesting mice are more aggressive

increased aggression towards mice ( J:322011 )

• in the resident-intruder paradigm test, mice show a shorter latency to the first biting attack, a higher attack frequency and longer total duration of attack episodes

abnormal response to novel object ( J:322011 )

• mice interact more with the novel object that is introduced in the home cage compared to wild-type mice, indicating increased impulsivity

abnormal response to social novelty ( J:322011 )

• in a three-chamber social behavior test, mice show no preference to stay with the stranger mice as seen in controls, indicating that mice have social preference injury

abnormal impulsive behavior control ( J:322011 )

• in the open field test, exposure to novel object, and novelty-suppressed feeding, mice show increased impulsive behavior, showing a greater total distance traveled in the open field, interacting more with the novel object, and having shorter eating latencies, respectively

abnormal nest building behavior ( J:322011 )

• mice show little or no nesting behavior

nervous system

decreased miniature excitatory postsynaptic current amplitude ( J:322011 )

• the amplitude of miniature excitatory postsynaptic currents (mEPSCs) is reduced in layer II/III pyramidal neurons of the medial prefrontal cortex

• however, mEPSC frequency is not different

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
antisocial personality disorder		DOID:10939		J:322011