Phenotypes Associated with This Genotype

Genotype
MGI:7258133

• Allelic Composition: Yars1^tm1.1Rwb/Yars1^tm1.1Rwb
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA-templated transcription ( J:310162 )

• induction of integrated stress response (ISR) in alpha motor neurons and whole spinal cord: upregulation of transcription of cellular stress-related genes at age 7 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease dominant intermediate C		DOID:0110199	OMIM:608323	J:310162