homeostasis/metabolism
• during the training stage of the treadmill test, mutant mice exhibit a stable performance at 6 and 12 months of age compared to controls which show decreased performance at 6 months
• during the fatigability stage of the treadmill test, mutant mice spend less time on the electrified grid than wild-type mice at 6 months of age
|
muscle
• 1-month-old mice show an increase in muscle tone
• however, no differences in grip test are seen in 1-18 month old mice and no muscle abnormalities are seen
|
behavior/neurological
N |
• behavior/neurological phenotype MP:0005386
mice do not show a difference on the rotarod and tail flick experiments show normal pain sensation
|
nervous system
N |
• sciatic nerves in 18-month-old mice appear normal, nerve conduction velocities and action potential amplitudes in sciatic nerves are normal, and no signs of peripheral neuropathy are seen
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | Charcot-Marie-Tooth disease type 2B1 | DOID:0110156 |
OMIM:605588 |
J:322912 |