Analysis Tools
liver/biliary system
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• livers show increased prominence of the vascular subcapsular markings, with appearance of a punctate pattern rather than a meshwork vascular pattern, in mice older than 6 months
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• scattered bleeding into necrotic and nonnecrotic liver areas with age
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• liver shows a mononuclear chronic inflammatory infiltrate which is nonregionalized and patchy with areas of necrosis
• however, Mallory body formation is not seen, and no differences in white cell, platelet, or red blood cell counts or other serum chemistry are seen
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• collagenase liver perfusion of young mice at an early stage when inflammation and necrosis are mild results in significant cell death indicating hepatocyte fragility
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• necrosis and bleeding into necrotic and nonnecrotic areas becomes highly prominent with age
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homeostasis/metabolism
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• elevation in serum glutamic-pyruvic transaminase
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• elevation in serum glutamic-oxaloacetic transaminase
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cardiovascular system
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• livers show increased prominence of the vascular subcapsular markings, with appearance of a punctate pattern rather than a meshwork vascular pattern, in mice older than 6 months
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• scattered bleeding into necrotic and nonnecrotic liver areas with age
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immune system
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• liver shows a mononuclear chronic inflammatory infiltrate which is nonregionalized and patchy with areas of necrosis
• however, Mallory body formation is not seen, and no differences in white cell, platelet, or red blood cell counts or other serum chemistry are seen
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