Phenotypes Associated with This Genotype

Genotype
MGI:7264822

• Allelic Composition: Dyrk1a^em1Kzy/Dyrk1a⁺
• Genetic Background: C57BL/6J-Dyrk1a^em1Kzy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:259596 )

• in the reverse learning phase of the Barnes maze task, mice tend to show a delay in acquiring the task, make more mistakes and travel longer distances than wild-type mice and have slower moving speed, indicating a delay in the acquisition of a new paradigm

• however, mice exhibit normal spontaneous activity, exploratory behavior, anxiety levels, behavior in the elevated plus maze, do not show obvious repetitive behavior and no differences in the tail suspension test or in the buried food task indicating no signs of depression-like behavior

abnormal long-term spatial reference memory ( J:259596 )

• in the reverse probe test of the Barnes maze task, mice make more mistakes to reach the target than wild-type mice, although they spend a similar amount of time investigating the target and remaining holes as wild-type mice indicating a mild deficit in spatial memory

cognitive inflexibility ( J:259596 )

• in the reverse learning phase of the Barnes maze task, mice show a delay in the acquisition of a new paradigm, however their show normal performance in the primary learning phase, suggesting that cognitive flexibility is affected

decreased aggression towards mice ( J:259596 )

• in the test tube for social dominance, mice lost 75% of confrontations and mice tend to retreat from the tube after nose-to-nose contact and short confrontations and the ratio of loss by retreat out of total number of losses is higher

decreased vertical activity ( J:259596 )

• number or rearing events in the open field is decreased

decreased social investigation ( J:259596 )

• mice spend less time investing the stranger mouse in the 3-chamber sociability test and show an increase in total traveled distance and average speed

• however, no differences are seen in the preference for social novelty

abnormal vocalization ( J:259596 )

• ultrasonic calls are shorter, of lower amplitude and lower frequency modulation

• the minimum frequency is higher, whereas the peak frequency is not different

• pups produce calls of lower complexity, producing the upward and short types at a higher rate and complex calls such as complex and harmonic types at a lower ratio than wild-type mice, and also produce fewer flat calls and a tendency for fewer two-syllable calls

decreased vocalization ( J:259596 )

• pups produce fewer ultrasonic calls

environmentally induced seizures ( J:259596 )

• mice show a mild susceptibility to seizures induced by hyperthermia but not by pentylenetetrazole or kainic acid injections, with mice showing generalized seizures at a slightly lower body temperature

• however, no abnormal epileptic patterns are seen at baseline

growth/size/body

decreased body weight ( J:259596 )

• short and transient, but significant, decrease in body weight from 2 months to 4 months of age

• however, in early postnatal development (P6) and in late adulthood (8 months) body weight is not different

nervous system

environmentally induced seizures ( J:259596 )

• mice show a mild susceptibility to seizures induced by hyperthermia but not by pentylenetetrazole or kainic acid injections, with mice showing generalized seizures at a slightly lower body temperature

• however, no abnormal epileptic patterns are seen at baseline

decreased brain weight ( J:259596 )

abnormal midbrain size ( J:259596 )

• the mesencephalic tectum is smaller

abnormal cerebral hemisphere morphology ( J:259596 )

• cerebrum is smaller

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant intellectual developmental disorder 7		DOID:0070037	OMIM:614104	J:259596