Phenotypes Associated with This Genotype

Genotype
MGI:7266256

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-IGF1R)1Ramo/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:271820 )

• mice administered doxycyline beginning at 21 days of age develop tumors on the lung surface as early as 90 days after doxycycline treatment

• most mice treated with doxycycline for up to 9 months exhibit visible lung tumors (2-30 tumors); tumors show multifocal adenomatous alveolar hyperplasia with papillary and solid adenomas

• mice in which doxycycline is removed after an 8-month treatment period show incomplete tumor regression

• however, bronchiolar hyperplasia is not seen in doxycycline treated mice

increased lung adenoma incidence ( J:271820 )

• solid adenomas are seen in doxycycline-treated mice

respiratory system

increased lung tumor incidence ( J:271820 )

• mice administered doxycyline beginning at 21 days of age develop tumors on the lung surface as early as 90 days after doxycycline treatment

• most mice treated with doxycycline for up to 9 months exhibit visible lung tumors (2-30 tumors); tumors show multifocal adenomatous alveolar hyperplasia with papillary and solid adenomas

• mice in which doxycycline is removed after an 8-month treatment period show incomplete tumor regression

• however, bronchiolar hyperplasia is not seen in doxycycline treated mice

increased lung adenoma incidence ( J:271820 )

• solid adenomas are seen in doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:271820