Phenotypes Associated with This Genotype

Genotype
MGI:7266261

• Allelic Composition: Mecp2^tm1Nlnd/Y
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:268051 )

♂ • males die prematurely, with an average lifespan of 97 days

growth/size/body

decreased body weight ( J:268051 )

♂ • males are lighter

behavior/neurological

abnormal behavior ( J:268051 )

♂ • males become progressively symptomatic with Rett-like features after weaning, with worsening of the general condition, tremors, hind limb clasping and highly variable altered mobility

limb grasping ( J:268051 )

♂ • hind limb clasping appears with age

tremors ( J:268051 )

♂ • tremor is the first symptom to appear

nervous system

decreased brain weight ( J:268051 )

♂ • brains from symptomatic males have a 15.7% weight reduction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:268051