Phenotypes Associated with This Genotype

Genotype
MGI:7266283

• Allelic Composition: Mecp2^tm1Nlnd/Mecp2⁺
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:268051 )

♀N • females do not show reduced longevity in the first year of life

growth/size/body

obese ( J:268051 )

♀ • body weight is indistinguishable from wild-type mice at early postnatal days but it progressively increases with aging, leading to obesity

behavior/neurological

abnormal behavior ( J:268051 )

♀ • females start showing Rhett-like features at 9 weeks of age, with worsening of the general condition and mobility, hind limb clasping and tremors

limb grasping ( J:268051 )

♀ • hind limb clasping appears with age

tremors ( J:268051 )

♀ • tremor is the first symptom to appear

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:268051