Phenotypes Associated with This Genotype

Genotype
MGI:7266284

• Allelic Composition: Mecp2^tm1.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial working memory ( J:268051 )

♂ • P30 males exhibit working memory defects, showing decreased percentage of correct alternation in the spontaneous alternation test

impaired coordination ( J:268051 )

♂ • males exhibit decreased latency to fall off the rotarod indicating motor impairment

decreased grip strength ( J:268051 )

♂ • P30 males exhibit decreased grip strength

short stride length ( J:268051 )

♂ • gait analysis indicates smaller strides in P30 males

muscle

increased muscle fatigability ( J:268051 )

♂ • males show increased muscle fatigue at constant speed on the rotarod

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:268051