Phenotypes Associated with This Genotype

Genotype
MGI:7266500

• Allelic Composition: Pde6b^rd1/Pde6b^rd1
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina blood vessel morphology ( J:322017 )

• mean venous diameter is decreased in 3- and 12-week-old mice

abnormal retina artery morphology ( J:322017 )

• mean arterial diameter is decreased in 3- and 12-week-old mice

thin retina ganglion layer ( J:322017 )

thin retina inner plexiform layer ( J:322017 )

abnormal retina nerve fiber layer morphology ( J:322017 )

• decrease in thickness

thin retina outer nuclear layer ( J:322017 )

thin retina outer plexiform layer ( J:322017 )

abnormal retina photoreceptor layer morphology ( J:322017 )

• decrease in thickness

decreased total retina thickness ( J:322017 )

• 12-week-old mice show thinning of the retinal layer, with a decrease in both the outer and inner retinal cell layer thickness

• however, inner nuclear layer thickness is not different

retina degeneration ( J:322017 )

abnormal eye physiology ( J:322017 )

• total retinal blood flow, rate of oxygen delivery from retinal circulation, and rate of oxygen extraction from the retinal circulation for metabolism are lower, however oxygen extraction fraction is not different

• total retinal blood flow and rate of oxygen delivery from retinal circulation are lower at 3 weeks of age compared to 12 weeks of age

cardiovascular system

abnormal retina blood vessel morphology ( J:322017 )

• mean venous diameter is decreased in 3- and 12-week-old mice

abnormal retina artery morphology ( J:322017 )

• mean arterial diameter is decreased in 3- and 12-week-old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinal degeneration		DOID:8466		J:322017