growth/size/body
• mice consistently weigh approximately 10% less than wild-type mice from P14 to P21
• males weigh 5% less and females weigh 10% less than wild-type mice at 2 months of age
• however, no reductions in head size nor gross brain morphology are seen
|
behavior/neurological
• mice show marginally but significantly worse neuroscores (consisting of the severity of impairment on ledge walking, hindlimb clasping, gait and kyphosis) between P16 and P23, indicating a small, but detectable, neurological deficit in young mice which resolves with age
• however, males do not show anxiety, hyperactivity, differences in sociability, spatial memory or repetitive behaviors: females were not tested due to motor deficiency
|
• adult females, but not males, show worse performance on the rotarod than controls
|
• females show reduced forelimb-only grip strength while both males and females have impaired all-limb grip strength at P22, however 8-week-old mice have normal grip strength
|
muscle
• females, but not males, exhibit a reduced muscle to body mass ratio; muscle weights of females are 79% those of wild-type mice, whereas total body weights are 90% of wild-type
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autosomal dominant intellectual developmental disorder 38 | DOID:0070068 |
OMIM:616393 |
J:296080 |