Phenotypes Associated with This Genotype

Genotype
MGI:7278773

• Allelic Composition: Acvr1^tm1Glh/Acvr1⁺; Gt(ROSA)26Sor^{tm1.2(CAG-EGFP)Glh}/Gt(ROSA)26Sor⁺; Tg(Pdgfra-cre)1Clc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:257905 )

• skeletal muscle exhibits pinch injury-induced heterotopic ossification

skeleton

increased bone ossification ( J:257905 )

• spontaneous heterotopic ossification is seen infrequently in some 2-week-old mice and is present in all 4-week-old mice and extensive in all surviving mice by 6 weeks of age

• heterotopic ossification is seen in the musculature, tendons, and ligaments at diverse locations

• skeletal elements resulting from spontaneous heterotopic ossification are derived almost exclusively from recombined cells

• all mice treated with an anti-activin A mAb prior to onset of heterotopic ossification for 4 weeks survive to 6 weeks of age and 8 of 9 mice show no evidence of heterotopic ossification and no spontaneous heterotopic ossification is not seen in treated 16-week-old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fibrodysplasia ossificans progressiva		DOID:13374	OMIM:135100	J:257905