Phenotypes Associated with This Genotype

Genotype
MGI:7280903

ht3

• Allelic Composition: Krt18^tm1Tmm/Krt18⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver inflammation ( J:309021 )

• livers show similar lobular and portal inflammation and ductular reaction as in homozygotes

abnormal liver morphology ( J:309021 )

• 17-20-month-old mice develop liver lesions resembling steatohepatitis

abnormal hepatocyte morphology ( J:309021 )

• hepatocytes with cleared-out cytoplasm are less abundant than in homozygotes and show zonal and disseminated distribution

Mallory bodies ( J:309021 )

• Mallory-Denk body (MDB)-containing hepatocytes are less frequent than in homozygotes and are found in about 40% of livers in males and about 9% of livers in females

• MDBs are less well developed than in homozygotes and granular inclusions prevail

hepatic steatosis ( J:309021 )

• aged mice develop liver steatosis to the same degree as in homozygotes; steatosis is more conspicuous in some females

increased liver tumor incidence ( J:309021 )

• approximately 73% of male and 22% of females develop liver tumors

• pleomorphic tumors are more frequent than monomorphic and more prevalent in males than females

neoplasm

increased liver tumor incidence ( J:309021 )

• approximately 73% of male and 22% of females develop liver tumors

• pleomorphic tumors are more frequent than monomorphic and more prevalent in males than females

immune system

liver inflammation ( J:309021 )

• livers show similar lobular and portal inflammation and ductular reaction as in homozygotes

cellular

chromosomal instability ( J:309021 )

• mice show chromosomal instability in liver at 12 months of age, before tumor formation