Phenotypes Associated with This Genotype

Genotype
MGI:7281484

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Myd88^em1.1Rsky/Myd88⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:308792 )

N • normal Ig class switching in germinal center B cells after immunization with hapten-carrier conjugate NP-CGG

N • normal rise and fall of hapten-specific IgG levels after immunization with hapten-carrier conjugate NP-CGG

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

immune system

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
monoclonal gammopathy of uncertain significance		DOID:7442		J:308792