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Phenotypes Associated with This Genotype
Genotype
MGI:7281485
Allelic
Composition		 Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre/ERT2)Rsky mutation (1 available); any Cd19 mutation (60 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

immune system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory