Analysis Tools
mortality/aging
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• mice start to die around 24 weeks of age
• renal failure is cause of death
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endocrine/exocrine glands
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• autoimmune destruction of the salivary gland
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• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
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• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice
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• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen
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immune system
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• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice
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• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen
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• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age
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• mice develop Sjogren's syndrome by 4 weeks of age, with females being more susceptible and presenting earlier onset of the disease than males
• mice show T cell-dominant immune cell infiltration in the salivary glands at 4 weeks and a gradual increase in the frequency of B cells, and an increase in anti-SSA and anti-SSB antibodies around 8 weeks of age
• transfer or T cells from mutant cervical lymph nodes, but not spleen, is sufficient to induce the development of Sjogren's syndrome in RAG2 null mice
• 3-day-old mice transferred with Treg cells derived from mature wild-type spleen show improved xerostomia, although saliva production is still reduced, a lesser degree of lymphocyte infiltration into salivary glands is seen and mice are protected against development of Sjogren's syndrome
• mice develop lupus nephritis
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• presence of anti-SSA and anti-SSB antibodies which are higher than in wild-type mice at 10 and 7 weeks of age, respectively
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• ANA are detected at high levels after 15 weeks of age
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• mice develop lupus nephritis after failure of salivary gland function
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digestive/alimentary system
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• autoimmune destruction of the salivary gland
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• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
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• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice
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hematopoietic system
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• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age
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homeostasis/metabolism
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• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
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• some mice exhibit proteinuria after 15 weeks of age
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renal/urinary system
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• some mice exhibit proteinuria after 15 weeks of age
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• mice develop lupus nephritis after failure of salivary gland function
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• IgM and IgG deposition, most likely a part of immune complexes, is seen around the glomerulus in the kidneys at 15 weeks of age
• a component of complement C3 is present in association with Ig deposition, suggestions that kidney lesions resembling lupus nephritis develop in aged mice
• no kidney lesions are seen at 4-5 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Sjogren's syndrome | DOID:12894 |
OMIM:270150 |
J:252606 | |
