Phenotypes Associated with This Genotype

Genotype
MGI:7281828

• Allelic Composition: Runx3^tm3Yg/Runx3^tm3Yg; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:243559 )

• severe

abnormal gait ( J:243559 )

• severely impaired gait pattern

• posterior placement of forelimbs and uncoordinated limb placement

• at 3 months of age gait regularity is substantially decreased

skeleton

scoliosis ( J:243559 )

• more pronounced curvature compared to mice with Tg(Pou4f1-cre/ERT2)2Jiz mediated recombination with about a 75% incidence

• bend is to the right of the coronal plane

nervous system

absent proprioceptive neurons ( J:243559 )

• absence of TrkC expressing neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
idiopathic scoliosis		DOID:0060250		J:243559