Phenotypes Associated with This Genotype

Genotype
MGI:7294376

cx11

• Allelic Composition: Il6^tm1Kopf/Il6⁺; Ncoa5^tm1Hxia/Ncoa5⁺
• Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:284227 )

♂ • SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5^tm1Hxia male heterozygotes

increased sperm motility ( J:284227 )

♂ • at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

increased sperm progressive motility ( J:284227 )

♂ • at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

enhanced male fertility ( J:284227 )

♂ • when bred with double heterozygous females, 5 out of 6 double heterozygous males are able to father litters with 2 to 8 pups per litter, in contrast to single Ncoa5^tm1Hxia male heterozygotes

abnormal epididymis physiology ( J:284227 )

♂ • at 4.5 months of age, IHC staining showed that epididymal expression of IL-6 is markedly lower than that in single Ncoa5^tm1Hxia male heterozygotes

cellular

teratozoospermia ( J:284227 )

♂ • SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5^tm1Hxia male heterozygotes

increased sperm motility ( J:284227 )

♂ • at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

increased sperm progressive motility ( J:284227 )

♂ • at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes