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Phenotypes Associated with This Genotype
Genotype
MGI:7310211
cn1
Allelic
Composition
Hif1atm1Stom/Hif1atm1Stom
Tg(Vil1-cre)20Syr/0
Genetic
Background
B6.Cg-Hif1atm1Stom Tg(Vil1-cre)20Syr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm1Stom mutation (0 available); any Hif1a mutation (50 available)
Tg(Vil1-cre)20Syr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• higher rectal temperature after cold challenge in mice fed a high-fat diet following a more significant drop in inguinal region
• however, response to is restored following oral or rectal administration of lactate
• in fasted mice fed a high-fat diet
• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal energy expenditure
• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice
• in the inguinal fat and epididymal fat of mice fed a high-fat diet after cold challenge along with increased mitochondrial CK activity
• however, treatment with lactate restores normal adaptive thermogenesis
• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal RER
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• especially conjugated bile acids TCA and tauro-beta-muricholic acid, and precursor DCA in mice fed a high-fat diet compared with control mice

digestive/alimentary system
• mice fed a high-fat diet exhibit inhibition of B. vulgatus and enrichment of R. torques associated with reduction in intestinal lactate levels compared with control mice

adipose tissue
• in mice fed a high-fat diet

growth/size/body
• in mice fed a high-fat diet
• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory