Phenotypes Associated with This Genotype

Genotype
MGI:7311570

• Allelic Composition: Lmna^tm1.1Otin/Lmna^tm1.1Otin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:261974 )

reproductive system

oligozoospermia ( J:261974 )

penis prolapse ( J:261974 )

♂

female infertility ( J:261974 )

♀ • due to reduced reproductive fitness

♀ • however, normal oocyte production and fertilization with wild-type sperm

reduced male fertility ( J:261974 )

♂

adipose tissue

decreased subcutaneous adipose tissue amount ( J:261974 )

• treatment with Remodelin partially rescues phenotype

cardiovascular system

abnormal aorta tunica adventitia morphology ( J:261974 )

• increased thickness that is partially rescued by Remodelin treatment

decreased heart rate ( J:261974 )

growth/size/body

decreased body weight ( J:261974 )

immune system

keratoconjunctivitis sicca ( J:261974 )

renal/urinary system

penis prolapse ( J:261974 )

♂

skeleton

kyphosis ( J:261974 )

vision/eye

keratoconjunctivitis sicca ( J:261974 )

cellular

oligozoospermia ( J:261974 )

integument

decreased subcutaneous adipose tissue amount ( J:261974 )

• treatment with Remodelin partially rescues phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:261974