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Phenotypes Associated with This Genotype
Genotype
MGI:7311574
Allelic
Composition		 Lmnatm1.1Otin/Lmna+
Nat10tm1a(KOMP)Wtsi/Nat10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Otin mutation (0 available); any Lmna mutation (84 available)
Nat10tm1a(KOMP)Wtsi mutation (2 available); any Nat10 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

skeleton
kyphosis ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

growth/size/body
decreased body weight ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
 J:261974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory