Phenotypes Associated with This Genotype

Genotype
MGI:7327617

• Allelic Composition: Insr^tm1Khn/Insr^tm1Khn; Tg(Pdgfrb-cre)#Rha/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:327000 )

• mice show increased vascularity in the regions adjacent to retinal veins

• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers

• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen

abnormal retina blood vessel morphology ( J:327000 )

• mice show increased retinal vein diameter at P5 and P10

abnormal retina blood vessel pattern ( J:327000 )

• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5

cardiovascular system

abnormal retina vasculature morphology ( J:327000 )

• mice show increased vascularity in the regions adjacent to retinal veins

• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers

• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen

abnormal retina blood vessel morphology ( J:327000 )

• mice show increased retinal vein diameter at P5 and P10

abnormal retina blood vessel pattern ( J:327000 )

• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5

abnormal vascular plexus formation ( J:327000 )

• mice exhibit abnormal retinal venous plexus development in early postnatal life, with increased branching complexity in the peripheral half of the plexus, increased venous plexus vascular density but not arterial plexus density, and increased vascular area of the deep vascular plexus indicating venous plexus hypervascularity

• perivenous hypervascularity diminishes with time, although it is still evident at P10

homeostasis/metabolism

increased circulating insulin level ( J:327000 )

• fasting serum insulin is increased in 8-week-old mice

• however, fasting serum glucose is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetic retinopathy		DOID:8947		J:327000