Phenotypes Associated with This Genotype

Genotype
MGI:7328859

• Allelic Composition: Myt1l^em1Mwer/Myt1l⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:326588 )

N • pups exhibit intact maternal odor preference in the homing test and normal basic motor function

N • social interaction behavior in adulthood appears unaffected, with normal emission of ultrasonic vocalizations during social interactions and during male-female and female-female interactions and normal behavior in the three-chamber assay

N • mice show normal grooming, spatial working memory in the Y-maze, and intact spatial learning and reversal learning

impaired contextual conditioning behavior ( J:326588 )

• mice, especially males, show reduced fear acquisition and contextual fear memory retrieval

abnormal habituation to a new environment ( J:326588 )

• habituation in the activity box is weak

• between-session habituation is weak

decreased anxiety-related response ( J:326588 )

• mice show reduced anxiety-related behavior in the elevated plus maze, spending more time in the open arms than controls

• however, mice do not show differences in locomotor activity in the open field under aversive conditions with bright light and in time spent in the center, or in the number of fecal boli

increased startle reflex ( J:326588 )

♂ • males, but not females, show increased acoustic startle responses to moderate and high sound intensities of 95, 15, and 115 db but no differences at 75 and 85 dB

♂ • males, but not females, show a potentiated startle response during presentation of a pulse of 115 dB in the absence of a pre-pulse

♂ • however, pre-pulse inhibition of acoustic startle is not affected indicating that sensorimotor gating is intact

impaired coordination ( J:326588 )

• overall motor performance on the accelerating rotarod is lower in the standard task and challenge task, particularly on the second day, where the latency to fall is lower during all three trials

• however, motor learning on the accelerated rotarod is intact

increased vertical activity ( J:326588 )

• mice show an increase in rearing in the activity box

increased locomotor activity ( J:326588 )

• mice show higher levels of locomotor activity during the first exposure to the activity box for 30 min, and locomotor activity levels remain high during the second exposure to the activity box the next day

• the increase in locomotor activity is due to a habituation defect

abnormal nest building behavior ( J:326588 )

• nest building behavior is affected, with mice building wider nests; nest width increases faster and to higher levels leading to higher nest quality

excessive vocalization ( J:326588 )

• pups emit more ultrasonic vocalizations of the high-frequency subtype than controls in the homing test

growth/size/body

obese ( J:326588 )

• mice become increasingly overweight

• males gain body weight faster and plateau at a higher level than controls after weaning

• females gain substantially more body weight after weaning and gain so much body weight during late adulthood that they reach body weight levels of males

• however, body weight is normal at P10 and body temperature at P10 and 14 months of age is not affected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant intellectual developmental disorder 39		DOID:0070069	OMIM:616521	J:326588