Phenotypes Associated with This Genotype

Genotype
MGI:7328939

• Allelic Composition: Bag5^em1Asay/Bag5^em1Asay
• Genetic Background: C57BL/6JJcl-Bag5^em1Asay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

pulmonary vascular congestion ( J:327046 )

• after continuous phenylephrine administration, mice exhibit more severe lung congestion than wild-type mice

abnormal myocardial fiber morphology ( J:327046 )

• cardiomyocytes show disturbed transverse tubule morphology

dilated heart left ventricle ( J:327046 )

decreased heart left ventricle muscle contractility ( J:327046 )

• hearts show reduced left ventricular ejection fraction

abnormal heart echocardiography feature ( J:327046 )

• echocardiography shows left ventricular dilatation and slightly reduced systolic function in the heart, with increased left ventricular end-diastolic volume and left ventricular end-systolic volume, and reduced left ventricular ejection fraction

ventricular tachycardia ( J:327046 )

• mice intraperitoneally injected with epinephrine and caffeine show more frequent episodes of ventricular tachycardia

ventricular premature beat ( J:327046 )

• mice intraperitoneally injected with epinephrine and caffeine show more frequent premature ventricular contractions

abnormal myocardial fiber physiology ( J:327046 )

• cardiomyocytes exhibit changes in calcium dynamics, with reduced amplitude and delayed decay of calcium transients

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:327046 )

• after continuous phenylephrine administration (catecholamine stimulation), mice show higher mortality than wild-type mice

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:327046 )

• after continuous phenylephrine administration (catecholamine stimulation), mice show higher mortality than wild-type mice

muscle

abnormal myocardial fiber morphology ( J:327046 )

• cardiomyocytes show disturbed transverse tubule morphology

decreased heart left ventricle muscle contractility ( J:327046 )

• hearts show reduced left ventricular ejection fraction

respiratory system

pulmonary vascular congestion ( J:327046 )

• after continuous phenylephrine administration, mice exhibit more severe lung congestion than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 2F		DOID:0081162	OMIM:619747	J:327046