Phenotypes Associated with This Genotype

Genotype
MGI:7329778

• Allelic Composition: Tg(Zfhx2*R1907K)#Jcox/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased chemical nociceptive threshold ( J:266472 )

• dorsal root ganglia neurons have a reduced response to capsaicin

increased thermal nociceptive threshold ( J:266472 )

• mice are hyposensitive to noxious heat; noxious heat pain thresholds are higher

nervous system

abnormal neuron physiology ( J:266472 )

• dorsal root ganglia neurons have a reduced response to capsaicin

• however, lumbar dorsal root ganglia show no differences in the number of peripherin+ neurons, indicating no loss of small diameter nociceptive neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Marsili syndrome		DOID:0081075	OMIM:147430	J:266472