Phenotypes Associated with This Genotype

Genotype
MGI:7329792

• Allelic Composition: Hmgcs2^em1(IMPC)Tcp/Hmgcs2⁺
• Genetic Background: C57BL/6NCrl-Hmgcs2^em1(IMPC)Tcp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:326918 )

• 8-week-old mice fed a high-fat diet for 8 weeks gain slightly more body weight than wild-type mice

• 8-week-old mice fed a high-fat diet for 8 weeks show an increase in fat mass

increased liver weight ( J:326918 )

• livers of 8-week-old mice are slightly heavier

homeostasis/metabolism

abnormal circulating ketone body level ( J:326918 )

• mice exhibit greater blood ketone levels than wild-type mice at P14 but are indistinguishable at weaning (P21)

• 8-week-old adult mice have lower fasting-induced blood ketone levels

• however, no differences in fed and fasted blood glucose levels are seen

liver/biliary system

increased liver weight ( J:326918 )

• livers of 8-week-old mice are slightly heavier

microvesicular hepatic steatosis ( J:326918 )

• livers of 8-week-old mice show greater microvesicular steatosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
HMG-CoA synthase 2 deficiency		DOID:0081168	OMIM:605911	J:326918