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Phenotypes Associated with This Genotype
Genotype
MGI:7331486
Allelic
Composition
Sar1bem1Emle/Sar1b+
Genetic
Background
C57BL/6N-Sar1bem1Emle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sar1bem1Emle mutation (0 available); any Sar1b mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit reduced triglyceride concentration after olive oil intragastric administration indicating intestinal fat malabsorption
• an increase in triglyceride and total cholesterol is seen in the gut following fat load
• mice show an increase in non-HDL cholesterol
• protein and gene expression analysis shows altered intestinal, but not liver, lipid metabolism, with a plausible enhancement of fatty acid beta-oxidation in the intestine and decline in lipogenesis process
• chylomicron lipid content shows lower triglyceride and total cholesterol content, indicating depressed chylomicron output

digestive/alimentary system
• mice exhibit reduced triglyceride concentration after olive oil intragastric administration indicating intestinal fat malabsorption
• an increase in triglyceride and total cholesterol is seen in the gut following fat load

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chylomicron retention disease DOID:0060357 OMIM:246700
J:319817


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory