Phenotypes Associated with This Genotype

Genotype
MGI:7341464

• Allelic Composition: Ftsj1^tm1Tomik/Y
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:328916 )

♂ • slight but significant decrease in body weight at 4 weeks of age

behavior/neurological

impaired contextual conditioning behavior ( J:328916 )

• mice show less freezing behavior in response to the context-dependent stimuli impaired fear memory retrieval

impaired cued conditioning behavior ( J:328916 )

• mice show less freezing behavior in response to the cue-dependent stimuli indicating impaired fear memory retrieval

impaired spatial learning ( J:328916 )

• mice show slower spatial learning in the Barnes maze test, with a higher error number in the first and second day of training

increased anxiety-related response ( J:328916 )

• 8-week-old mice spend less time and travel less distance in the center of the open-field chamber than wild-type time, while the total travel distance in the chamber does not differ

• in the elevated plus maze, mice spend less time and travel less distance in the open arm than wild-type mice, while the total travel distance in both the open arm and closed arm is longer, indicating anxiety-like behavior

nervous system

abnormal dendritic spine morphology ( J:328916 )

• mice exhibit an increase in the immature filopodia-like spines and a decrease in mushroom-type spines, indicating immature spine formation

• however, no obvious difference in the population of hippocampal and cortical neurons and glial cells in 8-week-old mice

abnormal dendritic mushroom spine morphology ( J:328916 )

• hippocampal and cortical neurons exhibit a decrease in mushroom type spines in 8-week-old mice

decreased dendritic spine density ( J:328916 )

• density of dendritic spines is decreased in hippocampal neurons

abnormal dendritic thin spine morphology ( J:328916 )

• hippocampal and cortical neurons exhibit an increase in thin dendritic spines in 8-week-old mice

abnormal postsynaptic density morphology ( J:328916 )

• decrease in the length and width of postsynaptic density in both hippocampal and cortical neurons

impaired synaptic plasticity ( J:328916 )

reduced long-term potentiation ( J:328916 )

• the normalized pEPSP slope of theta burst stimulation-evoked long term potentiation (LTP) shows a 50% reduction in hippocampus

reduced long-term depression ( J:328916 )

• the low-frequency stimulation induces only a slight decrease in the population excitatory postsynaptic potential (pEPSP) slope in hippocampal slices suggesting that long term depression (LTD) formation is impaired in the hippocampus

cardiovascular system

cardiovascular system phenotype ( J:328916 )

N • no morphological changes in the heart

liver/biliary system

liver/biliary system phenotype ( J:328916 )

♂N • no morphological changes in the liver

renal/urinary system

renal/urinary system phenotype ( J:328916 )

N • no morphological changes in the kidney

reproductive system

reproductive system phenotype ( J:328916 )

N • no morphological changes in the testis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-syndromic X-linked intellectual disability 9		DOID:0112034	OMIM:309549	J:328916