Phenotypes Associated with This Genotype

Genotype
MGI:7367456

• Allelic Composition: Aldh3a2^{tm1a(EUCOMM)Wtsi}/Aldh3a2^{tm1a(EUCOMM)Wtsi}; Aldh3b2^em1Akih/Aldh3b2^em1Akih
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:330263 )

• mice do not survive beyond P2 with absent milk spot and left outside of the nest

integument

impaired skin barrier function ( J:330263 )

hyperkeratosis ( J:330263 )

abnormal skin appearance ( J:330263 )

• rougher in texture than control mice with shallow sulcus cutis

homeostasis/metabolism

impaired skin barrier function ( J:330263 )

decreased ceramide level ( J:330263 )

• decreased acylceramide levels in the epidermis and stratum corneum

• however, mice exhibit normal levels of protein-bound ceramides in the epidermis

abnormal triglyceride level ( J:330263 )

• increased level of many triglyceride species in the epidermis

• however, total triglyceride levels are normal

growth/size/body

decreased body weight ( J:330263 )

• after birth

behavior/neurological

absent gastric milk in neonates ( J:330263 )

• associated with being left outside of the nest

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren-Larsson syndrome		DOID:14501	OMIM:270200	J:330263