Phenotypes Associated with This Genotype

Genotype
MGI:7378550

• Allelic Composition: Setd1a^em1Yzhg/Setd1a⁺
• Genetic Background: B6.Cg-Setd1a^em1Yzhg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sucrose solution preference ( J:328716 )

• mice show a slight but significant decrease in sucrose preference

anhedonia ( J:328716 )

• mice show a slight but significant decrease in sucrose preference

increased freezing behavior ( J:328716 )

• although mice show slightly higher freezing level before conditioning, mice show robust freezing behavior in postconditioning test as in wild-type mice

• however, mice show no differences in the open-field test, in social behavior, or in short-term memory during the Y-maze

nervous system

abnormal synaptic vesicle exocytosis ( J:328716 )

• K⁺-induced vesicle exocytosis in cortical and striatal neurons from newborns that were cultured in vitro for 18 days is reduced, indicating impaired presynaptic exocytosis

abnormal dendrite arborization pattern ( J:328716 )

• dendritic tree complexity of deep layer pyramidal neurons and medium spiny neurons is decreased in the prefrontal cortex and striatum, respectively

decreased dendritic spine density ( J:328716 )

• spine density is decreased in prefrontal cortex and striatum neurons

reduced sensorimotor gating ( J:328716 )

decreased prepulse inhibition ( J:328716 )

• prepulse inhibition is reduced, indicating an impairment of sensorimotor gating

• although mice show a slightly larger startle response, it is not statistically significant

cellular

abnormal synaptic vesicle exocytosis ( J:328716 )

• K⁺-induced vesicle exocytosis in cortical and striatal neurons from newborns that were cultured in vitro for 18 days is reduced, indicating impaired presynaptic exocytosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:328716