Phenotypes Associated with This Genotype

Genotype
MGI:7388558

• Allelic Composition: Mettl23^em2Itwa/Mettl23^em2Itwa
• Genetic Background: C57BL/6J-Mettl23^em2Itwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:330971 )

• mice exhibit normal intraocular pressure

retina ganglion cell degeneration ( J:330971 )

• significant at 6 months of age

optic nerve atrophy ( J:330971 )

• severe at 2 months of age

thin retina ganglion layer ( J:330971 )

• reduced ganglion cell complexes at 2 and 6 months of age with progressive axonal loss

abnormal rod electrophysiology ( J:330971 )

• reduced pSTR amplitudes of scotopic ERG at 6 months of age

nervous system

retina ganglion cell degeneration ( J:330971 )

• significant at 6 months of age

optic nerve atrophy ( J:330971 )

• severe at 2 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glaucoma		DOID:1686		J:330971