Phenotypes Associated with This Genotype

Genotype
MGI:7397265

cn1

• Allelic Composition: Phox2b^tm1Rth/Phox2b⁺; Tg(Fabp7-cre,-lacZ)3Gtm/0
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal suckling behavior ( J:331513 )

• pups fail to nurse and gain adequate body weight

respiratory system

decreased pulmonary respiratory rate ( J:331513 )

• mice show spontaneous/continuous breathing, albeit at a slightly reduced frequency, and do not exhibit cyanosis

nervous system

nervous system phenotype ( J:331513 )

N • mice show normal locus coeruleus tyrosine hydroxylase + populations and normal number of serotonergic neurons expressing tryptophan hydroxylase

abnormal retrotrapezoid nucleus morphology ( J:331513 )

• brainstems show loss of the retrotrapezoid nucleus

abnormal facial nerve morphology ( J:331513 )

• brainstems show loss of the seventh cranial nerve (CNVII) nuclei

• abnormal formation of CNVII in the embryonic brainstem is due to failure of precursor migration