Analysis Tools
mortality/aging
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• mice start to die at P11 and all die before 2 months of age
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• earliest time of death is at P11
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growth/size/body
weight loss
(
J:302917
)
|
• mice exhibit weight loss and smaller body size with increasing age
|
respiratory system
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• mice exhibit shortness of breath with increasing age
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cardiovascular system
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• mice show increased dilation of the ventricle chambers at P5
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• mice show increased cardiac fibrosis at P5
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• mice exhibit dilated cardiomyopathy by P23
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• mice show a decrease in left ventricular systolic function, showing a decrease in fractional shortening and ejection fraction, at P23
|
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• echocardiography at P23 shows enlarged left ventricular chamber size, wall thinning, decreased interventricular septal thickness at end systole and decreased left ventricular posterior wall thickness at end systole, and an increase in left ventricular internal diameter during both systole and diastole
|
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• mice develop heart failure
• congestion in the left ventricle and left atrium of hearts is seen after death
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behavior/neurological
hypoactivity
(
J:302917
)
|
• mice exhibit decreased spontaneous activity preceding death
|
muscle
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• mice exhibit dilated cardiomyopathy by P23
|
|
• mice show a decrease in left ventricular systolic function, showing a decrease in fractional shortening and ejection fraction, at P23
|
|
• sarcomere structure of heart shows minor defects at P5 but major alterations in myocardial structure at P23, including less, substantially short and dramatic disarrayed sarcomeres, irregular and wavy Z-disc and M-band
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• the M-band is irregular and wavy in myocardium at P23
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• irregular and wavy Z-disc and distribution of Z-disc is affected in myocardium at P23
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:302917 | |
